Description:

Third in a three-course sequence. Continues the lecture and lab component of CHEM& 261 and CHEM& 262. Topics include functional groups and biologically important compounds. Format includes laboratory work. Prerequisite: CHEM& 262.

Outcomes:

After completing this class, students should be able to:

• Aldehydes and Ketones
• Name and list typical properties of ordinary aldehydes and ketones
• Devise synthetic pathways to produce aldehydes and ketones
• List the differences in terms of reactivity between aldehydes and ketones
• Predict basic reactions of aldehydes, ketones, and alpha-carbons
• Write the mechanism for basic carbonyl reactions.
• Carboxylic Acids and Derivatives
• Name and list minimal properties of carboxylic acids, acid chlorides, acid anhydrides, esters, amides, and nitriles; list the relative reactivity of each
• Devise synthetic pathways between derivatives and from other families.
• Predict basic reactions of derivatives.
• Write the mechanism for all derivative-to-derivative reactions
• Dicarbonyls
• Explain the acidity of alpha carbons
• Predict the classic dicarbonyl reactions
• Amines
• Name and list typical properties of amines, including diazonium salts
• Devise synthetic pathways to produce both aliphatic and aromatic amines
• Predict basic amine reactions
• Write the mechanisms of the Hoffman and Curtius rearrangements
• Lipids and Amino Acids
• Identify the major lipid families, giving properties of each
• Identify isoprene units in typical terpenes and explain the mechanism of soap
• Show the differences between cationic, anionic, and zwitterionic forms of amino acids, and the implications for gel electrophoresis
• Proteins and Nucleic Acids
• Explain transcription and replication, and how it relates to mutation.
• Draw all possible DNA and RNA base pairs, including the phosphate backbone.
• Explain the four levels of protein structure, and the intermolecular forces that determine them. Also explain denaturing, induced fit, and chaperoning.
• Show how proteins are sequenced, and our current limitations